Method for ultrasound-mediated delivery system to monitor molecular penetration
US10076652B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Aug 10, 2015 |
| Grant date | Sep 18, 2018 |
| Priority date | — |
| Expiry date | Oct 25, 2036 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61M2205/3303
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
Methods to use medical imaging to monitor the molecule penetration into CNS during ultrasound-mediated delivery are disclosed. The method states a two-step process to predict the amount of molecular penetration which is based on the observation of medical imaging. The first is to propose a unified exposure input to unify the exposure condition so as to build a transferred relation to imaging index. The second is to propose a unified imaging index to unify the imaging readout so as to build a reliable transferred relation to molecular concentration. Linking these two, the molecular penetration induced by ultrasound irradiation can be estimated from medical imaging with ultrasound exposure conditions and molecular sizes.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.