Convergent approach to the total synthesis of telmisartan via a suzuki cross-coupling reaction
US10077242B2 · kind B2 · utility
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Key dates
| Filing date | Dec 1, 2015 |
| Grant date | Sep 18, 2018 |
| Priority date | — |
| Expiry date | Dec 1, 2035 |
Classification
- Technology area (CPC B)Performing Operations; Transporting
- CPC primaryB01J2531/842
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Methods of synthesizing the angiotensin II receptor antagonist telmisartan in high yield and purity are provided. The methods involve the coupling of two structurally distinct benzimidazole units via a Suzuki cross-coupling reaction. Methods of regioselectively synthesizing one of the benzimidazole units are also provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.