Patent · US Active

KCNQ potassium channel agonists, method of preparation and method of use thereof

US10077245B2 · kind B2 · utility

0Cited by

4References

15Claims

0Family size

Assignee

SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES · CN

Inventors

Fajun Nan · Shanghai, CN
Min Li · New Orleans, US
Zhaobing GAO · Shanghai, CN
Yangming Zhang · Shanghai, CN
Haining Hu · Shanghai, CN
Haiyan Xu · Beijing, CN
Huanan LIU · Shanghai, CN
Xiaoping Pi · Shanghai, CN

Key dates

Filing date	Apr 22, 2015
Grant date	Sep 18, 2018
Priority date	—
Expiry date	Apr 22, 2035

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07C2601/14
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The present invention provides a compound represented by general formula I or a pharmaceutical acceptable salt thereof, the preparation method therefor and the use thereof in preparing a medicine for treating a neurological disease, such as epilepsy, convulsion, neuropathic pain, acute ischemic stroke, and a neurodegenerative disease. The compound according to present invention has a better absorption in brain tissue when compared with RTG. In addition, the compound provided by present invention has not only a greatly enhanced efficacy, but also a neurotoxicity greatly lower than that of RTG, and thus possesses a wider safety window.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.