Bicyclic heterocyclic derivatives as bromodomain inhibitors

US10077259B2 · kind B2 · utility

Assignee

• ORION CORPORATION · FI

Inventors

• Susanta Samajdar · Savanuru, IN
• Chandrasekhar Abbineni · Hyderabad, IN
• Sanjita Sasmal · Kanchinakote, IN
• Subramanya Hosahalli · Bengaluru, IN

Key dates

• Filing date: Jan 6, 2015
• Grant date: Sep 18, 2018
• Expiry date: Jan 6, 2035

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/12
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present disclosure provides bicyclic heterocyclic derivatives of formula (I), which may be therapeutically useful, more particularly as bromodomain inhibitors; (I), in which R1, R2, R3, R4, L1, L2, Cy1, Cy2, X, n, and dotted line have the same meaning given in the specification, and pharmaceutically acceptable salts or pharmaceutically acceptable stereoisomers thereof that are useful in the treatment and prevention of diseases or disorders, in particular their use in diseases or disorders associated as bromodomain inhibitors. The present disclosure also provides preparation of compounds and pharmaceutical formulations comprising at least one of bicyclic heterocyclic derivatives of formula (I), together with a pharmaceutically acceptable carrier, diluent, or excipient.