Patent · US Active

Tubulysin analogs and methods of making and use

US10077287B2 · kind B2 · utility

0Cited by

5References

10Claims

0Family size

Assignee

Bristol-Myers Squibb Company · US

Inventors

Heidi L. Perez · Ewing, US
Donna D. Wei · Montgomery, US
Robert M. Borzilleri · Haneys Mill, US
Sanjeev Gangwar · Foster City, US
Gretchen M. Schroeder · Ewing, US
Heng Cheng · Millbrae, US
Robert J. Schmidt · Hainesport, US

Key dates

Filing date	Aug 24, 2015
Grant date	Sep 18, 2018
Priority date	—
Expiry date	Feb 21, 2036

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07K16/3046
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Tubulysin analogs of the formula (I) where R1, R2 R3, R4, R5, R6, R7, and Y are as defined herein, are anti-mitotic agents that can be used in the treatment of cancer, especially when conjugated to a targeting moiety.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.