Method for increasing the expression of anti-microbial peptides by keratinocytes comprising administering a composition comprising IL-17, TNF-alpha and OSM
US10080779B2 · kind B2 · utility
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2Claims
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Key dates
| Filing date | Sep 29, 2014 |
| Grant date | Sep 25, 2018 |
| Priority date | — |
| Expiry date | Sep 29, 2034 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2501/2306
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention disclosed herein relates to the field of epidermal repair and skin innate immunity. More particularly, the invention concerns the use of a mix of cytokines to inhibit keratinocyte differentiation, activate skin innate immunity, increase the expression of anti-microbial peptides, and improve epidermal repair. In particular, the invention concerns compositions comprising at least IL-17, TNFα and OSM that can be formulated for topical administration for cosmetic or dermatologic use.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.