Universal N-glycan binding reagent

US10080787B2 · kind B2 · utility

Assignee

• New England Biolabs, Inc. · US

Inventors

• Minyong Chen · Ipswich, US
• Xiaofeng Shi · Hunan, CN
• James C. Samuelson · Newburyport, US
• Christopher H. Taron · Marblehead, US

Key dates

• Filing date: Jun 26, 2015
• Grant date: Sep 25, 2018
• Expiry date: Jun 26, 2035

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Methods of capturing N-glycan linked glycomolecules including N-glycans, N-glycopeptides and N-glycoproteins are described. The methods provide substantially unbiased capture of charged and uncharged N-glycans and/or N-glycan linked glycomolecules. Binding reagents for substantially unbiased binding of N-glycans and/or N-glycan linked glycomolecules are also described.