Automated, multi-pot high-pressure radio-synthesizer for production of pet tracers

US10081005B2 · kind B2 · utility

Assignee

• The Regents of the University of California · US

Inventors

• Melissa Moore · Chicago, US
• R. Michael Van Dam · Los Angeles, US
• Kevin Quinn · Syracuse, US
• Shane Claggett · Seattle, US
• Henry Herman · Los Angeles, US
• Mark Lazari · San Fernando, US

Key dates

• Filing date: Mar 26, 2014
• Grant date: Sep 25, 2018
• Expiry date: Sep 17, 2035

Classification

• Technology area (CPC B): Performing Operations; Transporting
• CPC primary: B01J2219/00986
• WIPO field: Chemical engineering
• WIPO sector: Chemistry

Abstract

An automated radiosynthesizer device includes a plurality of reactor assemblies, each reactor assembly being operatively connected to a horizontal actuator for moving the reactor assembly in the horizontal direction and a vertical actuator for moving the reactor assembly in the vertical direction. A plurality of disposable cassettes are disposed above each of the plurality of reactor assemblies, each cassette comprising a lower surface comprising a plurality of sealed and un-sealed gaskets, wherein the un-sealed gaskets are connected to internal fluid paths within the cassette. The device includes a three-axis reagent and gas handling robot disposed above the plurality of cassettes and terminates in a vial gripper and a gas manifold having an inert gas port and a vacuum port. The device includes a control system configured to control the horizontal actuator and vertical actuator of each reactor assembly and the three-axis reagent and gas handling robot.