Patent · US Active

Using sortases to install click chemistry handles for protein ligation

US10081684B2 · kind B2 · utility

12Cited by

2References

24Claims

0Family size

Assignee

Whitehead Institute For Biomedical Research · US

Inventors

Hidde L. Ploegh · Brookline, US
Martin Witte · Ahaus, DE
Nicholas C. Yoder · Brookline, US

Key dates

Filing date	Jun 28, 2012
Grant date	Sep 25, 2018
Priority date	—
Expiry date	Aug 26, 2032

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07K2319/21
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

Methods and reagents for the installation of click chemistry handles on target proteins are provided, as well as modified proteins comprising click chemistry handles. Further, chimeric proteins, for example, bi-specific antibodies, that comprise two proteins conjugated via click chemistry, as well as methods for their generation and use are disclosed herein.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.