Derivation of human microglia from pluripotent stem cells
US10081792B2 · kind B2 · utility
2Cited by
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7Claims
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Key dates
| Filing date | Dec 31, 2015 |
| Grant date | Sep 25, 2018 |
| Priority date | — |
| Expiry date | Dec 31, 2035 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2513/00
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The present invention relates to methods for deriving human hematopoietic progenitors, primitive macrophages, and microglial cells from human pluripotent stem cells. In particular, provided herein are highly efficient and reproducible methods of obtaining human primitive macrophages and microglia from human pluripotent stem cells, where the primitive macrophages and microglia can be suitable for clinically relevant therapeutic applications.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.