Nucleotide sequencing using an array of independently addressable nanopores
US10081835B2 · kind B2 · utility
1Cited by
25References
15Claims
0Family size
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Key dates
| Filing date | Oct 17, 2013 |
| Grant date | Sep 25, 2018 |
| Priority date | — |
| Expiry date | Oct 17, 2033 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N33/48721
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Devices and methods that can detect and control an individual polymer in a mixture is acted upon by another compound, for example, an enzyme, in a nanopore are provided. The devices and methods also determine (˜>50 Hz) the nucleotide base sequence of a polynucleotide under feedback control or using signals generated by the interactions between the polynucleotide and the nanopore. The invention is of particular use in the fields of molecular biology, structural biology, cell biology, molecular switches, molecular circuits, and molecular computational devices, and the manufacture thereof.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.