Controlling fluid flow through an assay device

US10082502B2 · kind B2 · utility

Assignee

• ORTHO-CLINICAL DIAGNOSTICS, INC. · US

Inventors

• James D. Kanaley · Honeoye Falls, US
• Zhong Ding · Pittsford, US
• Philip C. Hosimer · Rochester, US
• Edward R. Scalice · Rochester, US
• Susan J. Danielson · Rochester, US
• David A. Tomasso · Rochester, US
• Timothy C. Warren · Rochester, US

Key dates

• Filing date: Feb 5, 2016
• Grant date: Sep 25, 2018
• Expiry date: Nov 11, 2036

Classification

• Technology area (CPC B): Performing Operations; Transporting
• CPC primary: B01L2400/086
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

An assay device includes: a detection zone which includes a first set of projections which are capable of generating capillary flow. A wicking zone (WZ) has a capacity to receive liquid sample flowing from the detection zone and includes a second set of projections which are capable of generating capillary flow. The WZ is rectangular in shape and the longer side of the rectangle extends in the direction of flow to thereby reduce the pressure gradient in the assay device which increases the total flow time of liquid sample compared to a WZ having equal length sides and same volume. At least a portion of the second set of projections have at least one dimension selected from a diameter, a center-to-center spacing, or a gap between projections that is different from the first set of projections, and is selected to increase the total flow time of the sample.