Materials and methods for treatment of cystic fibrosis and for induction of ion secretion
US10086007B2 · kind B2 · utility
2Cited by
1References
8Claims
0Family size
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Key dates
| Filing date | Mar 15, 2013 |
| Grant date | Oct 2, 2018 |
| Priority date | — |
| Expiry date | Mar 15, 2033 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/164
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides materials and methods for inducing ion secretion and/or for treating cystic fibrosis. In one embodiment, the composition comprises glucose and/or a non-metabolizable glucose analog and/or non-structural protein (NSP4), a NSP4 peptide, or a NSP4 toxoid as the active ingredient, formulated with pharmaceutically-acceptable carriers. In a preferred embodiment, the composition is in a form of an aerosol preparation for intranasal and/or pulmonary administration, and is used to stimulate chloride and fluid secretion in nasal, tracheal and/or bronchial epithelium.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.