Amino acid-, peptide- and polypeptide-lipids, isomers, compositions, and uses thereof

US10086013B2 · kind B2 · utility

Assignee

• Massachusetts Institute of Technology · US

Inventors

• Yizhou Dong · Lexington, US
• Kevin Love · Somerville, US
• Robert S. Langer · Newton, US
• Daniel Griffith Anderson · Framingham, US
• Delai Chen · Cambridge, US
• Yi-Hsiang Chen · New Taipei, TW
• Arturo Jose Vegas · Belmont, US
• Akinleye C. Alabi · Cambridge, US
• Yunlong Zhang · North Haven, US

Key dates

• Filing date: Nov 1, 2016
• Grant date: Oct 2, 2018
• Expiry date: Nov 1, 2036

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Described herein are compounds and compositions characterized, in certain embodiments, by conjugation of various groups, such as lipophilic groups, to an amino or amide group of an amino acid, a linear or cyclic peptide, a linear or cyclic polypeptide, or structural isomer thereof, to provide compounds of the present invention, collectively referred to herein as “APPLs”. Such APPLs are deemed useful for a variety of applications, such as, for example, improved nucleotide delivery. Exemplary APPLs include, but are not limited to, compounds of Formula (I), (II), (III), (IV), (V), and (VI), and salts thereof, as described herein: wherein m, n, p, R′, R1, R2, R3, R4, R5, R8, Z, W, Y, and Z are as defined herein.