Efficient protein expression in vivo using modified RNA (MOD-RNA)

US10086043B2 · kind B2 · utility

Assignees

• The General Hospital Corporation · US
• Children's Medical Center Corporation · US

Inventors

• Kenneth R. Chien · Cambridge, US
• Leon M. Ptaszek · Newton, US
• Oi-Lan Lui · Boston, US
• Lior Zangi · Brookline, US
• Wataru Ebina · Boston, US
• Derrick J. Rossi · Brookline, US

Key dates

• Filing date: Mar 12, 2012
• Grant date: Oct 2, 2018
• Expiry date: Mar 12, 2032

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2800/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Aspects of the invention described herein relate to synthetic, modified RNAs and their use in vivo to modulate gene expression. Aspects of the invention further relate to the use of these synthetic, modified RNAs in myocytes, cardiomyoctes, and tumors.