Methods and compositions related to retinoid receptor-selective pathway

US10087156B2 · kind B2 · utility

Assignees

• SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · US
• XIAMEN UNIVERSITY · CN

Inventors

• Xiao-kun Zhang · Village of La Jolla, US
• Ying Su · San Diego, US
• Hu Zhou · Shanghai, CN
• Wen Liu · Village of La Jolla, US
• Pei-Qiang Huang · Xiamen, CN

Key dates

• Filing date: Feb 16, 2017
• Grant date: Oct 2, 2018
• Expiry date: Feb 16, 2037

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2510/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Provided herein are methods and compositions related to a retinoid receptor-selective pathway. As described herein, this pathway can be targeted to manipulate a tumor microenviroment. For example, the methods and compositions described herein can be used to induce apoptosis in a cancer cell. Further, the compositions described herein, including Sulindac and analogs thereof, can be used to target this pathway for the treatment or prevention of cancer in human patients.