Scalable synthesis of reduced toxicity derivative of amphotericin B
US10087206B2 · kind B2 · utility
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13Claims
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Key dates
| Filing date | Oct 16, 2015 |
| Grant date | Oct 2, 2018 |
| Priority date | — |
| Expiry date | Oct 16, 2035 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07H1/00
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Disclosed is a simplified, readily scalable series of individual methods that collectively constitute a method for the synthesis of C2′epiAmB, an efficacious and reduced-toxicity derivative of amphotericin B (AmB), beginning from AmB. Also provided are various compounds corresponding to intermediates in accordance with the series of methods.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.