Patent · US Active

Alphabody libraries and methods for producing the same

US10087249B2 · kind B2 · utility

0Cited by

0References

9Claims

0Family size

Assignee

COMPLIX SA · LU

Inventors

Johan Desmet · Kortrijk, BE
Ignace Lasters · Ekeren, BE
Maria Henderikx · Hasselt, BE
Anita Wehnert · Maasmechelen, BE

Key dates

Filing date	Mar 11, 2016
Grant date	Oct 2, 2018
Priority date	—
Expiry date	Nov 12, 2036

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC40B50/12
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

The invention provides single-chain Alphabody library comprising at least 100 different-sequence single-chain Alphabody polypeptides, wherein said Alphabody polypeptides differ from each other in at least one of a defined set of 5 to 20 variegated amino acid residue positions, and wherein at least 70% but not all of said variegated amino acid residue positions are located either in the loop, helix surface or linker region of the Alphabody. The invention further provides methods for use of the Alphabody libraries and Alphabodies obtainable by the methods of the invention.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.