Fc-free antibodies comprising two fab-fragments and methods of use
US10087250B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Oct 3, 2013 |
| Grant date | Oct 2, 2018 |
| Priority date | — |
| Expiry date | Oct 3, 2033 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to bispecific antibodies comprising at least two Fab fragments, wherein the first Fab fragment comprises at least one antigen binding site specific for a first antigen; and the second Fab fragment comprises at least one antigen binding site specific for a second antigen, wherein either the variable regions or the constant regions of the second Fab heavy and light chain are exchanged and the two Fab fragments are connected to each other by two peptide linkers; and wherein the bispecific antibody is devoid of a Fc domain; methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.