Polycation-functionalized nanoporous silicon carrier for systemic delivery of gene silencing agents
US10087442B2 · kind B2 · utility
1Cited by
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17Claims
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Assignee
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Key dates
| Filing date | Dec 11, 2015 |
| Grant date | Oct 2, 2018 |
| Priority date | — |
| Expiry date | Dec 11, 2035 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2320/32
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Disclosed are methods and compositions containing functionalized nanoporous silicon particles, useful in a variety of diagnostic and/or therapeutic regimens for delivery of genetic constructs to one or more cells, tissues, and/or organs of interest. Also provided are methods for introducing into selected host cells one or more selected nucleic acid molecules. The present disclosure is also directed to a method of treating a tumor, comprising the step of administering to an individual one or more of the compositions and formulations thereof as described herein.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.