Volume response sensors having analyte controlled reversible crosslinking
US10088476B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Sep 29, 2014 |
| Grant date | Oct 2, 2018 |
| Priority date | — |
| Expiry date | Mar 22, 2035 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N33/66
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The invention relates to hydrogel and organogel sensors as well as their application to continuous analyte monitoring. The sensor can include a hydrogel or organogel matrix. Standard and inverse designed are provided. In one embodiment, the matrix can include a molecular recognition agent for an analyte (e.g., a glucose analyte), and a volume resetting agent that reversibly binds with the molecular recognition agent. Reversible crosslinks between the molecular recognition agent and volume resetting agent can change the volume of the matrix upon interacting with the analyte via a competitive binding process. In various embodiments, the invention provides a hydrogel-based glucose sensor and sensors for continuous glucose monitoring. The glucose sensor can be based on a glucose-responsive hydrogel with a volume linearly correlated with glucose concentrations, such as about 0.05-50 mM, under physiological conditions. The invention thus provides a blood glucose monitor suitable for use in clinical settings.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.