Inhibitors of polynucleotide repeat-associated RNA foci and uses thereof
US10092574B2 · kind B2 · utility
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Key dates
| Filing date | Sep 25, 2013 |
| Grant date | Oct 9, 2018 |
| Priority date | — |
| Expiry date | Sep 25, 2033 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K31/5375
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Compounds which inhibit the formation and/or accumulation of RNA foci, such as those due to polynucleotide repeats (e.g., trinucleotide repeats) are described herein. Also described herein are uses of such compounds, such as for the inhibition of the formation and accumulation such RNA foci, as well as for the treatment of polynucleotide repeat disorders (e.g., trinucleotide repeat disorders), such as myotonic dystrophy (e.g., DM1). Such compounds include compounds of formula 1, 1a, 1b, 2, 2a and (3) described herein.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.