Compounds for the treatment of medical disorders

US10092584B2 · kind B2 · utility

Assignee

• Achillion Pharmaceuticals, Inc. · US

Inventors

• Jason Allan Wiles · Madison, US
• Avinash Phadke · Branford, US
• Milind Deshpande · Madison, US
• Atul Agarwal · Hamden, US
• Dawei Chen · Middletown, US
• Venkat Rao Gadhachanda · Hamden, US
• Akihiro Hashimoto · Branford, US
• Godwin Pais · Hamden, US
• Qiuping Wang · Bethany, US
• Xiangzhu Wang · Madison, US

Key dates

• Filing date: Aug 25, 2016
• Grant date: Oct 9, 2018
• Expiry date: Aug 25, 2036

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P37/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds, methods of use, and processes for making inhibitors of complement Factor D comprising Formula I, or a pharmaceutically acceptable salt or composition thereof. The inhibitors described herein target Factor D and inhibit or regulate the complement cascade. The inhibitors of Factor D described herein reduce the excessive activation of complement.