Cyclic amides as MetAP-2 inhibitors

US10093623B2 · kind B2 · utility

Assignee

• Merck Patent GmbH · DE

Inventors

• Timo Heinrich · Groß-Umstadt, DE
• Frank Zenke · Darmstadt, DE
• Mireille Krier · Mühltal, DE
• Manja Friese-Hamim · Mörfelden, DE
• Jeyaprakashnarayanan Seenisamy · Bengaluru, IN

Key dates

• Filing date: Mar 21, 2013
• Grant date: Oct 9, 2018
• Expiry date: Mar 21, 2033

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Described are cyclic amide compounds of the formula (I): in which R1, R3, R5, R6, R7, R, X and Y have the meanings as described. The compounds are inhibitors of methionine aminopeptidase and can be employed for the treatment of tumors.