Substituted benzofuran, benzothiophene and indole MCL-1 inhibitors
US10093640B2 · kind B2 · utility
0Cited by
3References
21Claims
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Key dates
| Filing date | Sep 20, 2013 |
| Grant date | Oct 9, 2018 |
| Priority date | — |
| Expiry date | Sep 20, 2033 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D471/04
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides for compounds that inhibit the activity of an anti-apoptotic Bcl-2 family member Myeloid cell leukemia-1 (Mcl-1) protein. The present invention also provides for pharmaceutical compositions as well as methods for using compounds for treatment of diseases and conditions (e.g., cancer) characterized by the over-expression or dysregulation of Mcl-1 protein.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.