Genetically-modified cells comprising a modified human T cell receptor alpha constant region gene

US10093900B2 · kind B2 · utility

Assignee

• Precision BioSciences, Inc. · US

Inventors

• Derek Jantz · Durham, US
• James Jefferson Smith · Morrisville, US
• Michael G. Nicholson · Chapel Hill, US
• Daniel T. MacLeod · Durham, US
• Jeyaraj Antony · Chapel Hill, US
• Victor Bartsevich · Durham, US

Key dates

• Filing date: Apr 27, 2018
• Grant date: Oct 9, 2018
• Expiry date: Apr 27, 2038

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2510/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed herein is a genetically-modified cell comprising in its genome a modified human T cell receptor alpha constant region gene, wherein the cell has reduced cell-surface expression of the endogenous T cell receptor. The present disclosure further relates to methods for producing such a genetically-modified cell, and to methods of using such a cell for treating a disease in a subject.