Adsorption of immunopotentiators to insoluble metal salts

US10098949B2 · kind B2 · utility

Assignee

• GLAXOSMITHKLINE BIOLOGICALS SA · BE

Inventors

• Manmohan Singh · Cary, US
• David A. G. Skibinksi · Singapore, SG
• Tom Yao-Hsiang Wu · San Diego, US
• Yongkai Li · Del Mar, US
• Alex Cortez · San Diego, US
• Xiaoyue Zhang · San Diego, US
• Yefen Zou · San Diego, US
• Timothy Z. Hoffman · San Diego, US
• Jianfeng PAN · San Diego, US
• Kathy Yue · Riverside, US

Key dates

• Filing date: Apr 7, 2016
• Grant date: Oct 16, 2018
• Expiry date: Apr 7, 2036

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Immunopotentiators can be adsorbed to insoluble metal salts, such as aluminum salts, to modify their pharmacokinetics, pharmacodynamics, intramuscular retention time, and/or immunostimulatory effect. Immunopotentiators are modified to introduce a moiety, such as a phosphonate group, which can mediate adsorption. These modified compounds can retain or improve their in vivo immunological activity even when delivered in an adsorbed form.