Method and apparatus for improved resolution chromatography
US10099158B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | May 25, 2012 |
| Grant date | Oct 16, 2018 |
| Priority date | — |
| Expiry date | Nov 12, 2033 |
Classification
- Technology area (CPC B)Performing Operations; Transporting
- CPC primaryB01D15/10
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
An apparatus and a method are provided for column chromatography which provide improvements in separation resolution and detection sensitivity, comprising a chromatography column, the column having an inlet and an outlet, wherein the outlet is configured to split a flow of eluate as it leaves the column through the outlet into at least two separate portions, wherein the apparatus is configured to separately process the portions, for example to separately detect a portion or separately collect fractions of a portion with improved resolution. A split frit assembly is preferably configured to split the flow of eluate. The portions preferably emanate from different radial regions of the column. An end fitting for the column outlet may be provided having multiple ports to separately convey the portions.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.