Processes for preparing olaparib
US10100017B2 · kind B2 · utility
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15Claims
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Key dates
| Filing date | Aug 23, 2017 |
| Grant date | Oct 16, 2018 |
| Priority date | — |
| Expiry date | Aug 23, 2037 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D237/32
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Provided herein are novel processes and methods for making 4-[(3-[(4-cyclopropylcarbonyl)piperazin-1-yl]carbonyl)-4-fluorophenyl]methyl(2H)phthalazin-1-one (Olaparib) and intermediates thereof. Olaparib is a poly ADP ribose polymerase (PARP) inhibitor useful in the treatment of cancers. Benefits of the present disclosure include the use of less toxic compounds and improved yields.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.