Compound of 5-hydroxyl-1,7-naphthyridine substituted by aryloxy or heteroaryloxy, preparation method thereof and pharmaceutical use thereof

US10100051B2 · kind B2 · utility

Assignee

• Shenyang Sunshine Pharmaceutical Co., LTD · CN

Inventors

• Yunlong Zhou · Suzhou, CN
• Suixiong Cai · 安丰镇, CN
• Guangfeng Wang · Shanghai, CN
• Lingling Jiao · Taizhou City, CN
• Ping Min · Shanghai, CN
• Yu Jing · Suzhou, CN
• Ming Guo · Suzhou, CN

Key dates

• Filing date: Dec 14, 2015
• Grant date: Oct 16, 2018
• Expiry date: Dec 14, 2035

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P7/06
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A compound of 5-hydroxyl-1,7-naphthyridine substituted by aryloxy or heteroaryloxy, a preparation method thereof and a pharmaceutical use thereof are provided. In particular, the compound has the following Formula (I), wherein R2 and R3 are each independently H; R1 is H or C1-C3 alkyl; Ar is an aromatic ring or a heteroaromatic ring selected from a naphthalene ring, a pyridine ring, a thiophene ring, a furan ring and a substituted benzene ring. Pharmaceutically acceptable salts of the present compound, are provided, as well as uses of the compound or pharmaceutically acceptable salts thereof in the preparation of a medicine for inhibiting HIF prolyl hydroxylase or a medicine for promoting the generation of endogenous EPO.