Methods, compositions and screens for therapeutics for the treatment of synovial sarcoma
US10105420B2 · kind B2 · utility
12Cited by
2References
11Claims
0Family size
Assignee
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Key dates
| Filing date | Jul 20, 2016 |
| Grant date | Oct 23, 2018 |
| Priority date | — |
| Expiry date | Jul 25, 2036 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Q2600/16
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Methods and compositions are provided for treating human synovial sarcoma (SS). Also provided are screens to identify therapeutics for the treatment of synovial sarcoma. These methods, compositions, and screens are based on the discovery that promoting the assembly of wild type BAF (also called mSWI/SNF) complexes in SS cells by increasing levels of wild type SS18 and/or decreasing levels of SS18-SSX fusion protein leads to the cessation of proliferation of malignant cells in synovial sarcoma.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.