Isolated donor MHC-derived peptide and uses thereof
US10105425B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Apr 1, 2015 |
| Grant date | Oct 23, 2018 |
| Priority date | — |
| Expiry date | Apr 6, 2035 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2800/52
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention relates to an peptide derived from a polymorphic region of donor MHC class II molecules which induces tolerance and thus prevents transplant rejection in a patient in need thereof. The invention relates to an isolated peptide of 15 or 16 amino acids long that comprises or consists of the amino acid sequence: REEYARFDSDVGEYR (SEQ ID NO: 1) or a function-conservative variant for use as drug. The invention relates to an in vitro method for determining whether a transplanted patient is tolerant, comprising a step of determining the presence of CD8+CD45RClow Tregs in a biological sample obtained from said transplanted patient, wherein the presence of CD8+CD45RClow Tregs is indicative of tolerance.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.