Ultrashort peptides as exogenous second harmonic probes for bioimaging applications
US10105454B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Jul 8, 2015 |
| Grant date | Oct 23, 2018 |
| Priority date | — |
| Expiry date | Jul 27, 2035 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Q1/02
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Various aspects of the present invention relate to a peptide based biomaterial for visualization by SHG microscopy. In particular the invention relates to the use of short peptides as a non-linear optical (NLO) material for second harmonic generation (SHG) microscopy. A preferred short peptide comprises LIVAGK (LK6) and contains a non-polar aliphatic tail (with decreasing hydrophobicity) and a polar head; and can self-assemble into hydrogels; wherein which the peptide forms a tunable fibrous structure for in vitro and in vivo imaging applications and is suitable in disease diagnostics such as amyloidosis, including 1) neuro-degenerative amyloidosis, e.g. Alzheimer's (AD), Parkinson's, Huntington's (PD), 2) non-neuropathic localized amyloidosis such as in Type II Diabetes, and 3) systemic amyloidosis that occurs in multiple tissues, e.g. cataracts and lattice corneal dystrophy (LCD), as well as drug delivery and/or wound dressings.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.