HDAC6 inhibitors and their uses

US10106540B2 · kind B2 · utility

Assignees

• Universität Regensburg · DE
• Friedrich-Schiller-Universitat Jena · DE
• UNIVERSITÄTSKLINIKUM JENA · DE

Inventors

• Siavosh Mahboobi · Regensburg, DE
• Andreas Sellmer · Lappersdorf, DE
• Herwig Pongratz · Regensburg, DE
• Michel Leonhardt · Dachau, DE
• Oliver Krämer · Nackenheim, DE
• Frank-D Bohmer · Vacha, DE
• Gerhard Kelter · Ehrenkirchen, DE

Key dates

• Filing date: Aug 4, 2015
• Grant date: Oct 23, 2018
• Expiry date: Aug 4, 2035

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2603/18
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention relates to small molecule compounds and their use as HDAC inhibitors and in the treatment of various diseases, such as cancer. The present invention further relates to methods of synthesizing the compounds and methods of treatment. H-L(HA), H is a head group selected from (head group 1), (head group 2), (head group 3), (head group 4), (head group 5) and (head group 6).