Quantitative ligandomics for systematic identification of therapeutic ligands
US10106787B2 · kind B2 · utility
1Cited by
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6Claims
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Key dates
| Filing date | May 8, 2015 |
| Grant date | Oct 23, 2018 |
| Priority date | — |
| Expiry date | Jan 26, 2036 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2570/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention is directed to methods for systematic identification of cellular ligands, disease-associated ligands, age-related ligands and receptor-specific ligands. Disease-associated ligands are promising targets to develop novel ligand-based therapies. The methods are broadly applicable to any type of cells or diseases in in vitro and in vivo settings. This invention further used the methods to identify Scg3 as a disease-related angiogenic factor for the therapy of diabetic retinopathy, diabetic macular edema, proliferative diabetic retinopathy, vascular age-related macular degeneration, diabetic foot and cancers.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.