Modification of RNA, producing an increased transcript stability and translation efficiency

US10106800B2 · kind B2 · utility

Assignee

• BioNTech AG · DE

Inventors

• Ugur Sahin · Mainz, DE
• Silke Holtkamp · Mainz, DE
• Ozlem Tureci · Homburg, DE
• Sebastian Kreiter · Mainz, DE

Key dates

• Filing date: Jul 22, 2016
• Grant date: Oct 23, 2018
• Expiry date: Jul 22, 2036

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K2039/53
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

It was the object of the present invention to provide RNA with increased stability and translation efficiency and means for obtaining such RNA. It should be possible to obtain increased grades of expression by using said RNA in gene therapy approaches.