Methods of chemotype evolution
US10107798B2 · kind B2 · utility
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2References
57Claims
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Key dates
| Filing date | Mar 25, 2009 |
| Grant date | Oct 23, 2018 |
| Priority date | — |
| Expiry date | Apr 14, 2032 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2333/91205
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Herein is described a method to rapidly screen a large chemical space for a compound that binds to a target protein through an iterative fragment assembly approach that can be performed at low reagent cost and without requiring purification of the assembled product. The method employs a library of test ligands each of which comprise a ‘bait’ molecule, which is known from prior art or prior screening to have some intrinsic affinity for the target protein, and a test moiety.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.