Calmangafodipir, a new chemical entity, and other mixed metal complexes, methods of preparation, compositions, and methods of treatment

US10111893B2 · kind B2 · utility

Assignee

• PLEDPHARMA AB · SE

Inventors

• Jan-Olof Karlsson · Oslo, NO
• Karl E. Reineke · Niskayuna, US
• Tino Kurz · Säter, SE
• Rolf Andersson · Vikingstad, SE
• Michael Hall · Albany, US
• Christina McLaughlin · Albany, US
• Sven Jacobsson · Stockholm, SE
• Jacques Näsström · Bromma, SE

Key dates

• Filing date: Feb 28, 2017
• Grant date: Oct 30, 2018
• Expiry date: Feb 28, 2037

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07F19/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Methods for treatment of a pathological condition caused by oxidative stress in a patient comprise administering to the patient a mixed metal complex of a compound of Formula I, or a salt thereof, in an amount effective to reduce the oxidative stress. Pharmaceutical compositions are formed by suspending or dissolving a mixed metal complex of a compound of Formula I, or a salt thereof, in a liquid medium, optionally with one or more physiologically acceptable excipients. The mixed metals comprise calcium and manganese in a molar ratio of calcium to manganese in the range of 1-10: wherein X, R1, R2, R3, and R4 are as defined herein.