Asymmetrical hydrogenation reaction of ketonic acid compound
US10112884B2 · kind B2 · utility
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8Claims
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Key dates
| Filing date | Apr 28, 2015 |
| Grant date | Oct 30, 2018 |
| Priority date | — |
| Expiry date | Apr 28, 2035 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07F9/58
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention relates to the technical field of organic chemistry, specifically an asymmetrical hydrogenation of an ∂-ketonic acid compound, the technical proposal being as shown by the following formula:Wherein R1 is a phenyl, a substituted phenyl, a naphthyl a substituted naphthyl, a C1-C6 alkyl or aralkyl, the substitute is a C1-C6 alkyl, a C1-C6 alkoxy, a halogen, the number of the substituents is 1-3.M is a chiral spiro-pyridyl amido phosphine ligand iridium complex having the following structure,Wherein, R is hydrogen, 3-methyl, 4-tBu or 6-methyl
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.