Substituted cyanoguanidines as oral anti-virals

US10112911B2 · kind B2 · utility

Assignee

• Abb Vie Inc. · US

Inventors

• Artour Gomtsian · Vernon Hills, US
• Tatyana Dekhtyar · Libertyville, US
• Kristine E. Frank · Portage, US
• Michael Friedman · Jerusalem, IL
• Nathan S. Josephsohn · Boston, US
• M-Akhteruzzaman Molla · Gurnee, US
• Anil Vasudevan · Union Grove, US
• Iok Chan Ng · Arlington Heights, US
• Mikhail Chafeev · Khimki, RU

Key dates

• Filing date: Jun 28, 2013
• Grant date: Oct 30, 2018
• Expiry date: Jun 28, 2033

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D487/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This disclosure relates to: (a) compounds and salts of formula (I), formula (II), formula (III), and formula (IV), that, inter alia, inhibit RSV infection and/or replication; (b) intermediates useful for the preparation of such compounds and salts; (c) compositions comprising such compounds and salts; (d) methods for preparing such intermediates, compounds, salts, and compositions; (e) methods of use of such compounds, salts, and compositions; and (f) kits comprising such compounds, salts, and compositions.