15-oxospiramilactone derivatives, preparation method and uses thereof

US10112918B2 · kind B2 · utility

Assignees

• Kunming Institute of Botany, Chinese Academy of Sciences · CN
• The Key Laboratory of Chemistry for Natural Product of Guizhou Province and Chinese Academy of Science · CN
• Shanghai Institutes for Biological Sciences, CAS · CN
• INSTITUTE OF ZOOLOGY, CHINESE ACADEMY OF SCIENCES · CN

Inventors

• Xiaojiang Hao · Longchuan, CN
• Chen Yan · Guizhou, CN
• Haiyang Liu · Norman, US
• Lin Li · 安丰镇, CN
• Xiaoli He · Mechanicville, US
• Quan Chen · Madison, US

Key dates

• Filing date: Apr 21, 2014
• Grant date: Oct 30, 2018
• Expiry date: Aug 9, 2034

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2603/86
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention relates to a derivative of 15-oxospiramilacton, particularly to a compound of Formula I or II, or an isomer, a solvate or a pharmaceutically acceptable salt thereof. The invention also relates to a pharmaceutical composition comprising the compound as pharmaceutically active ingredient, a method for preparing the same, and use thereof in manufacture of an anti-tumor agent. The derivative of 15-oxospiramilactone of the invention have an activity against multiple tumor cell lines, and the anti-tumor activity is positively correlated to an activity inhibiting the Wnt signaling pathway.