N-[2-(2-amino-6,6-disubstituted-4,4a,5,6-tetrahydropyrano[3,4-d][1,3]thiazin-8a(8H)-YL)-1,3-thiazol-4-YL] amides

US10112958B2 · kind B2 · utility

Assignee

• PFIZER INC. · US

Inventors

• Michael Aaron Brodney · East Lyme, US
• Christopher Ryan Butler · Canton, US
• Lei Zhang · Beijing, CN
• Brian Thomas O'Neill · Old Saybrook, US
• Patrick Robert Verhoest · Newton, US
• Peter Mikochik · Groton, US
• John Charles Murray · East Lyme, US
• Xinjun Hou · Winchester, US

Key dates

• Filing date: Jul 11, 2017
• Grant date: Oct 30, 2018
• Expiry date: Jul 11, 2037

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D513/20
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention is directed to compounds, tautomers and pharmaceutically acceptable salts of the compounds which are disclosed, wherein the compounds have the structure of Formula I, and the variables R1, R2 and R3 are as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.