Methods for producing borylated arenes

US10112960B2 · kind B2 · utility

Assignees

• DOW AGROSCIENCES LLC · US
• BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY · US

Inventors

• Milton R. Smith, III · East Lansing, US
• Robert E. Maleczka · Lansing, US
• Hao Li · Brookline, US
• Chathurika R. K. Jayasundara · East Lansing, US
• Jossian Oppenheimer · Midland, US
• Dmitrijs Sabasovs · Haslett, US

Key dates

• Filing date: Sep 5, 2014
• Grant date: Oct 30, 2018
• Expiry date: Dec 29, 2035

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07F15/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Methods for the selective borylation of arenes, including arenes substituted with an electron-withdrawing group (e.g., 1-chloro-3-fluoro-2-substituted benzenes) are provided. The methods can be used, in some embodiments, to efficiently and regioselectively prepare borylated arenes without the need for expensive cryogenic reaction conditions.