Mutated immunoglobulin-binding polypeptides
US10112980B2 · kind B2 · utility
0Cited by
4References
25Claims
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Assignee
Inventors
Key dates
| Filing date | May 18, 2017 |
| Grant date | Oct 30, 2018 |
| Priority date | — |
| Expiry date | May 18, 2037 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K16/00
- WIPO fieldChemical engineering
- WIPO sectorChemistry
Abstract
The invention discloses a polypeptide with improved alkaline stability, which polypeptide comprises a mutant of a B or C domain of Staphylococcus Protein A (SpA), as specified by SEQ ID NO 1 or SEQ ID NO 2, or of Protein Z, as specified by SEQ ID NO 3, wherein at least the glutamic acid residue at position 15 has been mutated to an amino acid other than asparagine. The invention also discloses multimers of said polypeptide, as well as separation matrices comprising the multimers or polypeptides.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.