Insulin-like growth factor 1 receptor-specific antibodies and uses thereof

US10112998B2 · kind B2 · utility

Assignee

• National Research Council of Canada · CA

Inventors

• Danica Stanimirovic · Greely, CA
• Kristin Kemmerich · Ottawa, CA
• Arsalan S. Haqqani · Carp, CA
• Traian Sulea · Kirkland, CA
• Mehdi Arbabi-Ghahroudi · Ottawa, CA
• Bernard Massie · Laval, CA
• Renald Gilbert · Thurso, CA

Key dates

• Filing date: Dec 4, 2014
• Grant date: Oct 30, 2018
• Expiry date: Dec 4, 2034

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2800/28
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The blood-brain barrier (BBB) prevents transport of molecules larger than 500 Dal tons from blood to brain. Receptor-mediated transcytosis (RMT) facilitates transport across the BBB of specific molecules that bind receptors on brain endothelial cells that form the BBB. An insulin-like growth factor 1 receptor (IGF 1R)-binding antibody or fragment thereof is identified that transmigrates the BBB by RMT. The antibody or fragment is used to deliver a cargo molecule across the BBB, wherein the cargo molecule may be a therapeutic or detectable agent. The antibody is a camelid VHH, prepared by immunizing a llama with a 933-amino acid IGF 1R polypeptide. Humanized forms of the camelid VHH are also generated.