Variant polypeptides capable of aminating aliphatic alpha keto acids

US10113152B1 · kind B1 · utility

Assignee

• Abb Vie Inc. · US

Inventors

• Michael J. Abrahamson · Chicago, US
• Rajarathnam E. Reddy · Gurnee, US
• William T. Riordan · Libertyville, US
• Sanjay R. Chemburkar · Gurnee, US

Key dates

• Filing date: Oct 2, 2015
• Grant date: Oct 30, 2018
• Expiry date: Oct 2, 2035

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12Y104/01009
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

Disclosed are, among other things, variant polypeptides, nucleic acids encoding the polypeptides, production of the variant polypeptides, and use of the variant polypeptides in various applications, such as screening and synthetic methods. For example, the variant polypeptides, or enzymatically-active fragments thereof, are useful for converting aliphatic keto acids to aliphatic alpha amino acids.