Antigens of Pneumocystis murina and uses thereof

US10117913B2 · kind B2 · utility

Assignees

• Board of Supervisors of Louisiana State University · US
• University of New Orleans · US

Inventors

• Judd E. Shellito · New Orleans, US
• Alistair John Ramsay · New Orleans, US
• David Alan Welsh · Largo, US
• Sanbao Ruan · New Orleans, US
• Yang Cai · New Orleans, US

Key dates

• Filing date: May 4, 2015
• Grant date: Nov 6, 2018
• Expiry date: May 4, 2035

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K2039/55566
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A surface protein of the murine fungal pathogen Pneumocystis murina can be used to generate an immune response in a recipient animal or human that provides prophylactic protection and an anti-fungal activity in subjects already infected with a Pneumocystis species. Further, the disclosure provides novel polypeptides or peptides derived from the P. murina surface protein Surface Peptidase 1 (SPD-1) that are useful, alone or in combination with the SPD-1 polypeptide, in compositions and methods for the generation of an anti-Pneumocystis immune reaction by a recipient subject. The compositions and methods of the disclosure provide advantageous alternatives to available immunogenic determinants for the treatment or prevention of fungal pneumonia.