Antigen-specific T cell receptors and T cell epitopes

US10117918B2 · kind B2 · utility

Assignees

• BioNTech Cell & Gene Therapies GmbH · DE
• Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg-Universität Mainz Gemeinnützige GmbH · DE

Inventors

• Ugur Sahin · Mainz, DE
• Ozlem Tureci · Homburg, DE
• Petra Simon · Mainz, DE
• Tana Omokoko · Mainz, DE

Key dates

• Filing date: Dec 28, 2016
• Grant date: Nov 6, 2018
• Expiry date: Dec 28, 2036

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2333/916
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to efficient methods for providing antigen-specific lymphoid cells. These lymphoid cells may be used to provide antigen specific T cell receptors having a defined MHC restriction and to identify immunologically relevant T cell epitopes. Furthermore, the present invention relates to antigen-specific T cell receptors and T cell epitopes and their use in immunotherapy.