Chiral ligand-based metal-organic frameworks for broad-scope asymmetric catalysis

US10118169B2 · kind B2 · utility

Assignees

• THE UNIVERSITY OF CHICAGO · US
• The University of North Carolina at Chapel Hill · US

Inventors

• Wenbin Lin · Chicago, US
• Joseph M. Falkowski · Hampton, US
• Takahiro Sawano · Chicago, US

Key dates

• Filing date: Mar 30, 2015
• Grant date: Nov 6, 2018
• Expiry date: Mar 30, 2035

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02P20/54
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Metal-organic framework (MOFs) compositions based on chiral phosphine-, chiral oxazoline-, chiral pyridine-, and chiral diene-derived organic bridging ligands were synthesized and then post-synthetically metalated with metal precursors such as Ru and Rh complexes. The metal complexes could also be directly incorporated into the MOFs. The MOFs provide a versatile family of recyclable and reusable single-site solid catalysts for catalyzing a variety of asymmetric organic transformations, including the addition of arylboronic acids to α,β-unsaturated ketones and alkimines, the hydrogenation of substituted alkene and carbonyl compounds, and cyclization reactions. The solid catalysts can also be integrated into a flow reactor or a supercritical fluid reactor.