Patent · US Active

P-toluenesulfonate for MEK kinase inhibitor, and crystal form thereof and preparation method therefor

US10118911B2 · kind B2 · utility

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18Claims

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Assignee

JIANGSU HENGRUI MEDICINE CO., LTD. · CN

Inventors

Guaili Wu · 安丰镇, CN
Xiaohui Gao · 安丰镇, CN
Lin Bian · 安丰镇, CN
Junlei JIA · 安丰镇, CN

Key dates

Filing date	Mar 8, 2016
Grant date	Nov 6, 2018
Priority date	—
Expiry date	Mar 8, 2036

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07B2200/13
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Disclosed are a p-toluenesulfonate of a MEK kinase inhibitor, and a crystal form thereof and a preparation method thereof. Specifically disclosed are a 2-((2-fluorine-4-iodophenyl)amino)-1-methyl-4-((6-methylpyridine-3-group)oxygroup)-6-carbonyl-1,6-dihydropyridine-3-formamide p-toluenesulfonate (a compound represented by formula (I)), a crystal form I, and a preparation method thereof. The obtained crystal form I of the compound of formula (I) has good crystal form stability and chemical stability, and the crystallization solvent used has low toxicity and low residue, and is more suitable for use in clinical treatment.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.